Drug Repurposing Using Deep Embeddings of Gene Expression Profiles
نویسندگان
چکیده
منابع مشابه
DvD: An R/Cytoscape pipeline for drug repurposing using public repositories of gene expression data
SUMMARY Drug versus Disease (DvD) provides a pipeline, available through R or Cytoscape, for the comparison of drug and disease gene expression profiles from public microarray repositories. Negatively correlated profiles can be used to generate hypotheses of drug-repurposing, whereas positively correlated profiles may be used to infer side effects of drugs. DvD allows users to compare drug and ...
متن کاملNew drug candidates for treatment of atypical meningiomas: An integrated approach using gene expression signatures for drug repurposing
BACKGROUND Atypical meningiomas are common central nervous system neoplasms with high recurrence rate and poorer prognosis compared to their grade I counterparts. Surgical excision and radiotherapy remains the mainstay therapy but medical treatments are limited. We explore new drug candidates using computational drug repurposing based on the gene expression signature of atypical meningioma tiss...
متن کاملDNA microarray analysis of gene expression profiles in deep endometriosis using laser capture microdissection.
Endometriosis, a common gynecological disorder that causes infertility and pelvic pain, is defined as the presence of endometrial glands and stroma within extra-uterine sites. However, despite extensive studies its etiology and pathogenesis are not completely understood. Differentially expressed genes were investigated in epithelial and stromal cells from deep endometriosis and matched eutopic ...
متن کاملSpectral analysis of gene expression profiles using gene networks
or under-expression of individual genes, which is the cost to pay to obtain instead an interpretation in terms of more global pathways. Constraining the classifier to rely on just a few genes would have a similar effect of reducing the complexity of the problem,butwould lead to amoredifficult interpretation in terms of pathways. An advantage of our approach over other pathway-based clustering m...
متن کاملSpectral Analysis of Gene Expression Profiles Using Gene Networks
Motivation: Microarrays have become extremely useful for analysing genetic phenomena, but establishing a relation between microarray analysis results (typically a list of genes) and their biological significance is often difficult. Currently, the standard approach is to map a posteriori the results onto gene networks to elucidate the functions perturbed at the level of pathways. However, integr...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Molecular Pharmaceutics
سال: 2018
ISSN: 1543-8384,1543-8392
DOI: 10.1021/acs.molpharmaceut.8b00284